Views: 0 Author: Site Editor Publish Time: 2025-03-07 Origin: Site
In the pharmaceutical industry, the effectiveness and safety of drugs are of vital importance. These characteristics of drugs depend largely on the particle size and distribution of their active ingredients. Traditional crushing and homogenization methods often have problems such as low efficiency, uneven particle size distribution, and easy contamination. The emergence of ultrasonic homogenizers provides an efficient, precise, and clean solution for the pharmaceutical industry, and can be called a "cell crushing expert."
1. Working principle of ultrasonic homogenizer
Ultrasonic homogenizers use the high-frequency vibrations generated by ultrasound in liquids to form a "cavitation effect." When the ultrasonic energy is high enough, a large number of tiny bubbles will be generated in the liquid, which will expand and burst rapidly, generating strong shock waves and microjets. This powerful mechanical force can effectively break cells and disperse particles, thereby achieving a homogenizing effect.
2. Application of Ultrasonic Homogenizer in Pharmaceutical Industry
Ultrasonic homogenizer is widely used in pharmaceutical industry, mainly including the following aspects:
Drug extraction: Ultrasound can destroy plant cell walls and increase the extraction rate of effective ingredients, such as extracting flavonoids and polysaccharides from plants.
Nanodrug preparation: Ultrasound can break drug particles to the nano level, improving the solubility and bioavailability of drugs, such as preparing nanoliposomes and nanoemulsions.
Vaccine preparation: Ultrasound can break bacteria and viruses and is used for inactivation and attenuation of vaccines, such as preparing rabies vaccines and influenza vaccines.
Drug dispersion: Ultrasound can evenly disperse drugs in solvents to improve the stability and efficacy of drugs, such as preparing suspensions and emulsions.
Compared with traditional methods, ultrasonic homogenizer has the following advantages:
Efficient: Ultrasonic homogenization is fast and efficient, which can significantly shorten production time.
Uniform: Ultrasonic homogenization has good effect and uniform particle size distribution, which can improve the quality and efficacy of drugs.
Clean: The ultrasonic homogenization process does not require the addition of chemical reagents, avoids pollution, and meets GMP requirements.
Controllable: Ultrasonic parameters are adjustable and can be optimized according to different materials and process requirements.
